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This Concept Map, created with IHMC CmapTools, has information related to: Tangier Disease, macrophages accumulation of cholesterol which was contained in oxidized LDL/VLDL causes transformation to foam cells, VLDL contains Apo B-100, LPL and hepatic lipase by removing TAGs, converts VLDL into IDL, oxidized LDL engulfed by and accumulates in macrophages, Heterozygous patient for ABCA1 mutation has mutation in 1 allele for ABCA1 gene, arterial macrophages accumulation of cholesterol which was contained in oxidized LDL/VLDL causes transformation to foam cells, peripheral tissues specifically including tonsils, ABCA1 protein encoded by ABCA1 gene, Autosomal Recessive trait for ABCA1 gene, VLDL engulfed by and accumulates in arterial macrophages, Tangier's Disease is expressed biochemically as Autsomal CoDominant trait, peripheral tissues accumulation of intracellular cholesterol causes downregulation of LDL Receptor, Homozygous patient for ABCA1 mutation has mutation in both alleles for ABCA1 gene, Cholesterol transferred from HDL to VLDL, CETP acts on HDL, VLDL hydrolyzed by LPL and hepatic lipase, Tangier's Disease is expressed clincally as Autosomal Recessive trait, Homozygous patient for ABCA1 mutation has no functional ABCA1 protein, ABCA1 gene mutation causes Tangier's Disease, LDL contains Apo B-100